San Francisco 49ers’ Jimmy Garoppolo, George Kittle exit in fourth quarter with

The San Francisco 49ers lost quarterback Jimmy Garoppolo and tight end George Kittle to fourth-quarter ankle and foot injuries, respectively, late in Sunday’s game against the Seattle Seahawks.

Kittle’s and Garoppolo’s injuries came within minutes of each other, and both retreated to the locker room for further examination. Both were listed as questionable to return. Those injuries came after running back Tevin Coleman left in the first quarter with a knee injury.

Garoppolo seemed to tweak his left ankle earlier in the game but played through it before he was removed with 14:02 left to play. Garoppolo limped to the locker room after going 11-of-16 for 84 yards with no touchdowns and an interception for a passer rating of 55.2. Nick Mullens stepped in for Garoppolo.

It’s the second ankle injury Garoppolo has suffered this season. He sustained a high right ankle sprain in Week 2 against the New York Jets, an injury that cost him the two games that followed and part of a third game the next week after he struggled in his return against the Miami Dolphins.

Kittle’s foot injury came with 12:36 to play after he leaped to haul in a 25-yard pass from Mullens. Kittle made the play but came down awkwardly on the ankle and hobbled to the sideline soon after. Initially thought to be an ankle injury, the 49ers said it was a foot issue.

Kittle had two catches for 39 yards when he departed, and Ross Dwelley replaced him.

One day after the Niners activated Coleman, who had spent the previous five games on injured reserve with a sprained knee, he was unable to make it through the first quarter of Sunday’s game against the Seahawks.

With 5:42 left in the first quarter, Coleman took a handoff to the left side and gained 12 yards on second-and-10. But he got up slowly and hobbled to the sideline immediately after the play.

At halftime, the Niners said Coleman was questionable to return with a knee injury, but they ruled him out soon after. Coleman had three carries for 20 yards before departing.

The loss of Coleman left the Niners with just rookie JaMycal Hasty and veteran Jerick McKinnon available at running back. McKinnon has had a limited role in recent weeks after a heavy workload early in the season, leaving Hasty to get many of the opportunities.

Hasty scored his first NFL touchdown in the second quarter.

The 49ers entered Sunday’s game without starting running back Raheem Mostert and backup Jeff Wilson Jr., both of whom are on injured reserve with high ankle sprains.